NDLI: Phagocytic cells synthesize 19-nor-10-keto-25-hydroxyvitamin D3, a metabolite that may induce differentiation of the human monoblastic cell line U937.

Content Provider	Semantic Scholar
Author	Gray, T. Kenney Millington, David S. Maltby, David A. Williams, Mark E. Cohen, Michael S. Dodd, Richard C.
Copyright Year	1985
Abstract	Phagocytic cells, including normal human blood neutrophils and monocytes, metabolize 25-hydroxyvitamin D3 in vitro to more polar metabolites. Cells of the human monoblastic cell line U937 produced three metabolites when incubated with 25-hydroxyvitamin D3. One of these metabolites, previously designated peak III, has its maximal absorbance at 310 nm. Mass spectral analysis of the trimethylsilylated derivatives of peak III revealed a spectral pattern very similar to that published for the trimethylsilylated derivatives of 19-nor-10-keto-25-hydroxyvitamin D3. The biosynthetic 19-nor-10-keto-25-hydroxyvitamin D3 was active in the induction of differentiation of U937 cells.
File Format	PDF HTM / HTML
DOI	10.1073/pnas.82.23.8218
PubMed reference number	3865223
Journal	Medline
Volume Number	82
Issue Number	23
Alternate Webpage(s)	http://www.pnas.org/content/82/23/8218.full.pdf
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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