Loading...
Please wait, while we are loading the content...
The immediate effects of acoustic trauma on the inferior colliculus: a Wiener-kernel analysis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Heeringa, Amarins N. Dijk, Pim Van |
| Copyright Year | 2015 |
| Abstract | Noise-induced tinnitus and hyperacusis are thought to correspond to a disrupted balance between excitation and inhibition in the central auditory system. We have previously shown that properties of excitation and inhibition of the inferior colliculus (IC) can be studied using Wiener-kernel analysis. The current study aimed at investigating the effects of immediate acoustic trauma on excitatory and inhibitory components of the IC, as revealed with Wienerkernel analyses. Neural responses were recorded from the IC of three anesthetized albino guinea pigs before and immediately after a one-hour bilateral exposure to an 11-kHz tone of 124 dB SPL. Before and after the traumatizing stimulus, neural activity was recorded during the presentation of a 1-h continuous Gaussian-noise stimulus of 70 dB SPL for Wiener-kernel analysis. Response characteristics obtained with Wiener-kernel analyses were complemented with excitatory and inhibitory responses to pure tones. Both spontaneous and noise-evoked firing rates were significantly decreased immediately after acoustic trauma. Furthermore, multi units were tuned to lower frequencies as compared to before acoustic trauma. Wiener-kernel analysis showed that excitation and inhibition in low-CF multi units (CF < 3 kHz) was not affected, inhibition in mid-CF multi units (CF between 3 kHz and 11 kHz) disappeared whereas excitation was not affected, and both excitation and inhibition in high-CF multi units (CF > 11 kHz) disappeared after acoustic trauma. This specific differentiation could not be identified with the tone-evoked receptive-field analyses, in which inhibitory responses disappeared in all units and excitatory responses in only the high-CF units. With this study, we showed that the effects of acoustic trauma can be identified with Wiener-kernel analysis. We confirmed an acoustic trauma-induced disrupted balance between excitation and inhibition, which was apparent in mid-CF units in particular. Our findings might give additional insight in the central pathophysiological mechanisms of noiseinduced hyperacusis. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.rug.nl/research/portal/files/20379903/Chapter_5.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
