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Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites
| Content Provider | Semantic Scholar |
|---|---|
| Author | Li, Yong-Tong Woodruff-Pak, Diana S. Trojanowski, John Q. |
| Copyright Year | 1994 |
| Abstract | We probed serial and near serial sections of cerebellum from 13 Alzheimer's disease (AD), 10 older Down's syndrome (DS) patients, and 9 age-matched, non-AD controls, using single and double labeling immunohistochemistry to investigate the pathologic consequences of beta-amyloid or A4 (A beta) deposits in cerebellum and their relationship to Purkinje cells (PCs). Our data showed that A beta deposits in cerebellum of AD and older DS adults only form diffuse or preamyloid plaques and the density of A beta lesions per unit area of molecular layer correlated with the number of PCs per unit length of the subjacent PC layer in double immunostained sections (r = 0.85; p < 0.001). About 65% of these cerebellar A beta deposits were in physical contact with PC dendrites. No A beta plaques were found in the cerebellum of controls. Despite the abundance of A beta deposits in the cerebellar cortex of AD and older DS patients, neither PC bodies nor PC dendrites in physical contact with A beta lesions showed evidence of structural abnormalities. |
| Starting Page | 1 |
| Ending Page | 9 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0197-4580(94)90139-2 |
| PubMed reference number | 8159255 |
| Journal | Medline |
| Volume Number | 15 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0197458094901392 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0197458094901392?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0197-4580%2894%2990139-2 |
| Journal | Neurobiology of Aging |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
