NDLI: Studies on the Synthetic and Biological Activity of Some Organotin ( IV ) Derivatives of Hexanedioic Acid

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Studies on the Synthetic and Biological Activity of Some Organotin ( IV ) Derivatives of Hexanedioic Acid

Content Provider	Semantic Scholar
Author	Iornumbe, E. N. Yiase, Stephen G. Sha'ato, Rufus
Copyright Year	2016
Abstract	This study assessed the antimicrobial activity of four synthesized organotin (IV) derivatives of potassium hydrogen hexanedioate, L: Bu2SnL2 (1), Bu3SnL (2), Ph2SnL2 (3) and Ph3SnL (4). The compounds were tested for antimicrobial activity against four strains of Gram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Bacillus cereus, Corynebacterium ulcerans, four strains of Gramnegative Bacteria: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa and four fungi strains of :Histoplasma capsulatum, Mucor mucedor, Penicillium helicium and Penicillium chrysogenum. Result showed that the compounds synthesized in general exhibited greater antibacterial and antifungal activity than the potassium hydrogen hexanedioate, L, and hexanedioc acid at minimum inhibition concentration(MIC) of 7.5 – 15 μg/mL , minimum bactericidal concentration (MBC) of 15 – 60 μg/mL and minimum fungicidal concentration(MFC) of 2550 μg/mL. Activities were very closed to that shown by standard drugs: erythromycin, fluconazole and ketoconazole. Organotin moieties are known to play a vital role in deciding the biological activity of an organotin compound, this is true in this work as the order of antibacterial activity was potassium triphenyltin (IV) hexanedioate (4) >potassium tributyltin (IV) hexanedioate (2)> potassium diphenyltin (IV) hexanedioate (3)> potassium dibutyltin (IV) hexanedioate(1). The order of antifungal activity was potassium tributyltin (IV) hexanedioate (2)> potassium triphenyltin (IV) hexanedioate (4)> potassium diphenyltin(IV) hexanedioate (3)> potassium dibutyltin (IV) hexanedioate(1).
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.iosrjournals.org/iosr-jac/papers/vol9-issue7/Version-1/C0907012332.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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