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Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Dyck, Christopher H. Van Malison, Robert Staley, Julie K. Jacobsen, Leslie K. Seibyl, John P. Laruelle, Marc Baldwin, Ronald M. Innis, Robert B. Gelernter, Joel |
| Copyright Year | 2004 |
| Abstract | OBJECTIVE A functional polymorphism has been described in the promoter region of the gene (SLC6A4) coding for the serotonin transporter protein (SERT). This polymorphism has two common alleles, designated as long and short. Each allele has been linked with a number of human clinical phenotypes, including neuropsychiatric diseases associated with dysregulation of serotonin transmission. In vitro studies of nonneural cells have suggested that the long allele may have higher transcriptional activity than the short allele. However, the relevance of these findings for SERT levels in the brain remains unclear. METHOD The authors assessed genotypes at the SLC6A4 promoter polymorphism in 96 healthy European American subjects who underwent single photon emission computed tomography scanning with [123I]2beta-carbomethoxy-3beta-(4-iodophenyl) tropane ([123I]beta-CIT) for measurement of central SERT availability. A ratio of specific to nondisplaceable brain uptake (i.e., V3"=[brainstem-diencephalon-occipital]/occipital), a measure proportional to the binding potential (Bmax/KD), was derived. RESULTS The results showed that the main effect of genotype was significant. Post hoc Tukey pairwise comparisons revealed that the short-short homozygotes had significantly greater SERT availability than the long-short heterozygotes. There was a nonsignificant tendency for the long-long homozygotes to have greater SERT availability than the heterozygotes, but no difference was observed between the long-long homozygotes and the short-short homozygotes. The effect of age was significant in the analysis of covariance model. CONCLUSIONS These results do not suggest higher central SERT levels in association with the long allele in European American subjects but point to a more complex relationship between SLC6A4 genotype and protein availability. |
| Starting Page | 1189 |
| Ending Page | 1194 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ils.unc.edu/bmh/neoref/nrschizophrenia/jsp/review/tmp/391.pdf |
| Alternate Webpage(s) | https://ils.unc.edu/bmh/neoref/nrschizophrenia/jsp/review/tmp/391.pdf |
| PubMed reference number | 14992979v1 |
| Volume Number | 161 |
| Issue Number | 3 |
| Journal | The American journal of psychiatry |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alleles Benztropine Carrier Proteins Genotype Heterozygote Homozygote Immune System Diseases Phenotype Photons Promoter Regions, Genetic SLC6A4 gene SLC6A4 wt Allele Structure of diencephalon Tomography, Emission-Computed Tomography, Emission-Computed, Single-Photon Transcription, Genetic Tropanes X-Ray Computed Tomography serotonin transporter |
| Content Type | Text |
| Resource Type | Article |
