Loading...
Please wait, while we are loading the content...
Similar Documents
Relishing Regulation and Receptors Hormones and Signaling, Volume 1 Edited by Bert W. O'Malley et al. San Diego, CA: Academic Press (1998). 364 pp. $69.95
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rosenfeld, Michael G. |
| Copyright Year | 1999 |
| Abstract | discussing the role of hormones and growth factors in In summary, this ambitious and timely undertaking by Dickson and Salomon is well worth having as a reference postnatal development focus primarily on reproductive tract and mammary gland development. Here, these bio-and addresses issues not currently covered by standard textbooks in the field (i.e., Williams Textbook of Endocri-logical systems demonstrate that any cell–cell communication (i.e., autocrine and paracrine signaling) can be nology or Gilbert's Developmental Biology textbook). Remarkably, there have been very few concerted efforts considered to be hormone action. This broader definition is nicely illustrated in Cunha's chapter on reproduc-to integrate hormone signaling with development and cancer. Given that these fields are advancing rapidly, tive tract development and in the two chapters describing prolactin signaling in mammary gland development we predict that this excellent book will only improve with subsequent editions. by Hennighausen and Vonderhaar. In considering how hormones influence reproductive development, a relevant topic that was not formally covered in this section, the potential of environmental agents, mimicking hor-San Francisco, California 94143–0444 mones, to cause developmental defects in humans and wildlife. Since hormone responsiveness in the embryo may be fundamentally different from that in the adult tool to dissect hormone signaling in development and neoplasia from signaling in normal adult physiology. Hormones and Signaling, Volume 1 Perhaps, the second edition of this book will include a Edited by Bert W. O'Malley et al. dedicated chapter devoted to this important issue. The final section of this book focuses on current research detailing the roles of sex steroids, peptide hormones , and growth factors in formation and progression Deciphering the molecular mechanisms that underlie the of human cancers. In a number of these reviews, the integration of extracellular and intracellular signals and prominent role of steroids, such as estrogens and andro-direct transcriptional responses in development, ho-gens, in reproductive tissue cancers is clearly outlined. meostasis, and transformation has been the focus of However, one is also reminded that the search for ste-intense investigation over the present decade using di-roid-responsive target genes relevant to tumorigenesis verse organisms as models. Contemporary technolo-is far from over. Furthermore, we still do not understand gies have catalyzed a deluge of information that has how these types of cancers progress into a hormone-rapidly altered models in this area. The challenge to independent growth phase. It is implied that cross-talk organize and interpret this data presents a particular between … |
| Starting Page | 477 |
| Ending Page | 479 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0092-8674(00)80647-9 |
| Volume Number | 96 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0092867400806479 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0092867400806479 |
| Alternate Webpage(s) | https://doi.org/10.1016/S0092-8674%2800%2980647-9 |
| Journal | Cell |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
