NDLI: Laminine während der Knorpelentwicklung, im gesunden Knorpel und deren Bedeutung für die Pathogenese der Osteoarthritis des Menschen

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Laminine während der Knorpelentwicklung, im gesunden Knorpel und deren Bedeutung für die Pathogenese der Osteoarthritis des Menschen

Content Provider	Semantic Scholar
Author	Schminke, Boris
Copyright Year	2011
Abstract	The laminin subunits α1, α3, α5, β1, and γ1 were detected in this study as components of the extracellular matrix of human cartilage and in the mesenchymal limb systems, and by all, except for laminin-α1, was not known that they occur in this at all. Generally it was found that more laminin is present in osteoarthritic cartilage than in the healthy. It was noticeable that men express more laminin α3 as women who suffer from osteoarthritis than men known to frequent. It was shown that the amount of laminin to the elongated chondrocytes or chondrogenic progenitor cells from the late stages of osteoarthritis was increased the most. This indicates that regeneration activity. It was also shown that osteoarthritic chondrocytes Lamininstimulation of a reinforced expression of components of the extracellular matrix, which corresponds to normal conditions causes. This also suggests a role of laminin-chains for the regenerative potential of chondrogenic progenitor cells. At the end of adhesive properties have been shown specific for chondrocytes in the late stages of osteoarthritis, chondrocytes and lit-laminin interactions in more detail. Total of the results can be concluded that the studied laminins the chondrocytes and the chondrogenic progenitor cells help possible regeneration processes carried out and restore the integrity of cartilage in the late stages of osteoarthritis. Therefore, it seems possible that these play a key role in the pathogenesis of osteoarthritis.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://ediss.uni-goettingen.de/bitstream/handle/11858/00-1735-0000-0006-B1E4-D/schminke.pdf?sequence=1
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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