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Prodromal Dementia with Lewy Bodies and Prodromal Alzheimer's Disease: A Comparison of the Cognitive and Clinical Profiles.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sadiq, Dilman Whitfield, Tim J. Stevens, Tim Van Costafreda, Sergi G. Walker, Zuzana |
| Copyright Year | 2017 |
| Abstract | BACKGROUND Dementia must be diagnosed accurately and early in the disease course to allow pathology-specific treatments to be effective. Dementia with Lewy bodies (DLB) is often misdiagnosed as Alzheimer's disease (AD), especially at the prodromal stage. OBJECTIVE To compare the clinical and neuropsychological profiles of Mild Cognitive Impairment (MCI) patients who, at follow-up, progressed to AD (retrospectively AD-MCI) or DLB (retrospectively DLB-MCI) or remained MCI. METHODS This longitudinal study used an unselected sample from a memory clinic database. A total of 1,848 new patients were seen at the memory clinic between 1994-2015. Of these, 560 patients (30%) had an initial diagnosis of MCI and were considered for the study. Inclusion criteria were patients who had a diagnosis of MCI at initial assessment and a minimum of 12 months' follow-up. RESULTS Of the 429 MCI patients with follow-up data, 164 (38%) remained MCI, 107 (25%) progressed to AD, and 21 (5%) progressed to DLB. The remainder progressed to alternative diagnoses. At baseline, DLB-MCI patients performed significantly worse on visuospatial function and letter fluency tests than both AD-MCI and stable-MCI groups, and better on episodic memory tests than the AD-MCI group. At baseline, DLB-MCI patients had a significantly higher mean UPDRS score and were more likely to have REM sleep behavior disorder and fluctuating cognition. CONCLUSION DLB-MCI patients have a specific cognitive and neuropsychiatric profile which should alert clinicians to the possibility of prodromal DLB. This is relevant when considered in the context of early disease-specific therapy. |
| Starting Page | 463 |
| Ending Page | 470 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://discovery.ucl.ac.uk/10056300/1/Walker_Prodromal%20Dementia%20with%20Lewy%20Bodies%20and%20Prodromal%20Alzheimer%E2%80%99s%20Disease.%20A%20Comparison%20of%20the%20Cognitive%20and%20Clinical%20Profiles_AAM.pdf |
| PubMed reference number | 28453473v1 |
| Alternate Webpage(s) | https://doi.org/10.3233/JAD-161089 |
| DOI | 10.3233/JAD-161089 |
| Journal | Journal of Alzheimer's disease : JAD |
| Volume Number | 58 |
| Issue Number | 2 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alert:Type:Point in time:^Patient:Nominal Alzheimer's Disease Behavior Disorders Bodies - cell components CDISC Questionnaire ADCS-ADL MCI Test Name Terminology Cognition Disorders Disease Progression Lewy Body Disease Longitudinal Studies Memory Disorders Mild cognitive disorder Patients Presenile dementia Prodromal Stage Prodromal Symptoms REM Sleep Behavior Disorder Unified Parkinson's Disease Rating Scale Questionnaire |
| Content Type | Text |
| Resource Type | Article |
