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Activation of EGF receptor kinase by L1-mediated homophilic cell interactions.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Islam, Rafique Ul Kristiansen, Lars V. Romani, Susana García-Alonso, L. A. Hortsch, Michael |
| Copyright Year | 2004 |
| Abstract | Neural cell adhesion molecules (CAMs) are important players during neurogenesis and neurite outgrowth as well as axonal fasciculation and pathfinding. Some of these developmental processes entail the activation of cellular signaling cascades. Pharmacological and genetic evidence indicates that the neurite outgrowth-promoting activity of L1-type CAMs is at least in part mediated by the stimulation of neuronal receptor tyrosine kinases (RTKs), especially FGF and EGF receptors. It has long been suspected that neural CAMs might physically interact with RTKs, but their activation by specific cell adhesion events has not been directly demonstrated. Here we report that gain-of-function conditions of the Drosophila L1-type CAM Neuroglian result in profound sensory axon pathfinding defects in the developing Drosophila wing. This phenotype can be suppressed by decreasing the normal gene dosage of the Drosophila EGF receptor gene. Furthermore, in Drosophila S2 cells, cell adhesion mediated by human L1-CAM results in the specific activation of human EGF tyrosine kinase at cell contact sites and EGF receptors engage in a physical interaction with L1-CAM molecules. Thus L1-type CAMs are able to promote the adhesion-dependent activation of EGF receptor signaling in vitro and in vivo. |
| Starting Page | 95 |
| Ending Page | 106 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.molbiolcell.org/content/15/4/2003.full.pdf |
| PubMed reference number | 14718570v1 |
| Volume Number | 15 |
| Issue Number | 4 |
| Journal | Molecular biology of the cell |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Axon Fasciculation Axon Guidance Binding (Molecular Function) Cell Adhesion Molecules EGFR protein, human Epidermal Growth Factor Receptor Fibroblast Growth Factor Gonadotropin-Releasing Hormone Receptor L1CAM wt Allele Muscular fasciculation Neurogenesis Neuronal Outgrowth Pharmacology Promotion (action) Protein Tyrosine Kinase Receptor Protein-Tyrosine Kinases |
| Content Type | Text |
| Resource Type | Article |
