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Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domains
Article
Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domains
Article
Wnt Binding Affinity Prediction for Putative Frizzled-Type Cysteine-Rich Domains
| Content Provider | Semantic Scholar |
|---|---|
| Author | Agostino, Mark Pohl, Sebastian Öther-Gee |
| Copyright Year | 2019 |
| Abstract | Several proteins other than the frizzled receptors (Fzd) and the secreted Frizzled-related proteins (sFRP) contain Fzd-type cysteine-rich domains (CRD). We have termed these domains "putative Fzd-type CRDs", as the relevance of Wnt signalling in the majority of these is unknown; the RORs, an exception to this, are well known for mediating non-canonical Wnt signalling. In this study, we have predicted the likely binding affinity of all Wnts for all putative Fzd-type CRDs. We applied both our previously determined Wnt‒Fzd CRD binding affinity prediction model, as well as a newly devised model wherein the lipid term was forced to contribute favourably to the predicted binding energy. The results obtained from our new model indicate that certain putative Fzd CRDs are much more likely to bind Wnts, in some cases exhibiting selectivity for specific Wnts. The results of this study inform the investigation of Wnt signalling modulation beyond Fzds and sFRPs. |
| File Format | PDF HTM / HTML |
| DOI | 10.3390/ijms20174168 |
| PubMed reference number | 31454915 |
| Journal | Medline |
| Volume Number | 20 |
| Alternate Webpage(s) | https://res.mdpi.com/d_attachment/ijms/ijms-20-04168/article_deploy/ijms-20-04168.pdf |
| Alternate Webpage(s) | https://doi.org/10.3390/ijms20174168 |
| Journal | International journal of molecular sciences |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
