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Expression of Glutamate Transporters EAAC1, GLAST, GLT-1 in Neonatal White Matter Play a Role in Brain Excitotoxicity
| Content Provider | Semantic Scholar |
|---|---|
| Author | Huria, Tahani R. Elmrghni, Samir |
| Copyright Year | 2018 |
| Abstract | Previous studies have focussed on the expression of glutamate transporters in myelinated and mature mice optic nerves. This work investigates glutamate transporters expression in isolated immature rat optic nerves (day 0) (P0) in which myelination has not yet commenced. We have revealed the cellular distribution of glutamate transporters in the neonatal white matter using embedded Electron Microscopy. All three types of glutamate transporters found in the sub-cortical white matter in the post-natal period. Our current work examined the sub-cellular distribution of EAAC1, GLAST and GLT1 proteins in the perinatal white matter using immune histochemistry techniques. Recent studies have revealed the rapid astrocyte swelling will liberate astrocyte glutamate into the extracellular space in a glutamate-dependent fashion usually via GLAST and GLT1 transport result in necrosis of neonatal ischaemic white matter. It is suggested that glutamate release from NF-H +axons via reverse transport which was potentially a vital factor in excitotoxic and non-excitotoxic ischemia of the perinatal white matter. We conclude that extensive expression of GLAST and GLT1 on the perinatal astrocyte processes play a role in brain excitotoxicity |
| File Format | PDF HTM / HTML |
| Volume Number | 01 |
| Alternate Webpage(s) | https://www.elynspublishing.com/article-download/expression-of-glutamate-transporters-eaac1-glast-glt-1-in-neonatal-white-matter-play-a-role-in-brain-excitotoxicity |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
