NDLI: Antígenos plaquetários humanos HPA1, HPA3 e HPA5 e risco de eventos vaso-oclusivos em portadores de anemia falciforme de Salvador

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Antígenos plaquetários humanos HPA1, HPA3 e HPA5 e risco de eventos vaso-oclusivos em portadores de anemia falciforme de Salvador – Bahia

Content Provider	Semantic Scholar
Author	Adorno, Elisângela Vitória Almeida, Handerson Fabrício Costa De Laranjeira, Débora Santana Almeida, Mari Ney Tavares Gonçalves, Marilda De Souza
Copyright Year	2010
Abstract	The sickle cell anemia (SCA) is characterized by clinical manifestations heterogeneous, proceeding from hemolytics and vosocclusive events (VOE). Currently, the molecule activation and expression of adhesion in leukocytes, platelets and endothelial cells have been associates to the VOE. Thus, the present study it investigated genetic polymorphisms in glycoproteins gene of platelets (GP) associating them it the hematological data and clinical profile of the patients. The casuistry was of 77 individuals with SCA and medium of age of nine years (the 0 17 years). The clinical data had been gotten of medical handbooks; the molecular evaluations had been carried through by reaction in chain of polymerase followed by the digestion with enzymes of restriction (RCP-RFLP) and the statistical analyses in the program EPINFO, version 6.04. In this group, 59 (76.6%) individuals had presented hospitalization, 41 (52.3%) had blood transfusion and 60 (77.9%) had presented at least a vasoocclusive event. The analysis for the polymorphism Hpa1 located in the GPIIIa gene demonstrated 53 (68.8%) homozygous for allele, 23 (29.9%) heterozygous and one (1.3%) homozygous b; the research of the polymorphism Hpa3 (GPIIb) was identified in 70 individuals, demonstrating 27 (38.6%) homozygous, the 35 (50.0%) heterozygous and eight (11.4%) homozygous b; the polymorphism Hpa5 (GPIa) demonstrated the 54 (70.1%) homozygous and 23 (29.9%) heterozygous. The results had not demonstrated to association between the polymorphisms and the clinical profile of the carriers of SCA of Salvador, Bahia State. However, we consider of basic importance the association of these polymorphisms with the molecule expression of adhesion in platelets, in way to directly test a possible participation of these in vaso-occlusive phenomenon.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.arca.fiocruz.br/bitstream/icict/7962/1/Adorno%20EV%20Ant%C3%ADgenos%20plaquetarios....pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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