NDLI: Protein cross-linking by transglutaminase induced in long-term potentiation in the CA1 region of hippocampal slices

Please wait, while we are loading the content...

Protein cross-linking by transglutaminase induced in long-term potentiation in the CA1 region of hippocampal slices

Content Provider	Semantic Scholar
Author	Friedrich, Péter Fesus, Làszlò Tarcsa, Edit Czéh, Gábor
Copyright Year	1991
Abstract	Long-term potentiation induced by high-frequency stimulation of Schaffer collaterals in slices of rat hippocampus is accompanied by protein cross-linking by the Ca(2+)-dependent enzyme transglutaminase. This conclusion was drawn from the accumulation of the "isodipeptide" epsilon(gamma-glutamyl)lysine in the proteolytic digests of tetanized, but not of control, slices. The isopeptide bond is formed by transglutaminase between glutamyl-gamma-CONH2 and lysyl-epsilon-NH2 groups of proteins. It is suggested that the Ca(2+-induced covalent cross-linking of neuronal, probably dendritic, proteins may be part of the mechanism of long-term plastic changes via stabilization of newly formed supramolecular protein assemblies at the synapse.
Starting Page	331
Ending Page	334
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0306-4522(91)90297-2
PubMed reference number	1681463
Journal	Medline
Volume Number	43
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0306452291902972
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0306452291902972?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0306-4522%2891%2990297-2
Journal	Neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in