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A cholinergic connection between normal aging and senile dementia in the human hippocampus
| Content Provider | Semantic Scholar |
|---|---|
| Author | Perry, Elaine K. Perry, Robert H. Gibson, Peter H. Blessed, Garry Tomlinson, Bernard E. |
| Copyright Year | 1977 |
| Abstract | Abstract The cholinergic enzyme, choline acetyltransferase (CAT) has been estimated in autopsy brain tissue obtained from elderly, mentally normal and abnormal hospital patients, including those with senile dementia. In the normal subjects a substantial loss of cortical CAT occurred with increasing age and was most pronounced in the hippocampus. Of the age-matched abnormal groups investigated, significantly reduced enzyme activities were found in the group with senile dementia, in which the hippocampal loss was most extensive. These findings indicate a vulnerability of the hippocampal cholinergic system in old age and dementia which may be associated with memory derangement. |
| Starting Page | 85 |
| Ending Page | 89 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(77)90070-2 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394077900702 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394077900702?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 19605034 |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2877%2990070-2 |
| Journal | Medline |
| Volume Number | 6 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
