A Comprehensive Comparison of Solid Phase Extraction ( SPE ) vs . Solid Liquid Extraction ( SLE ) vs . Liquid Liquid Extraction ( LLE ) Sample Prep Techniques in Bioanalysis and Forensic Toxicology Analyses

Content Provider	Semantic Scholar
Author	Danaceau, Jonathan P. Haynes, Kim
Copyright Year	2017
Abstract	■ ■ Flexible sample capacity options with Oasis PRiME HLB compared with SLE (rigid sample amount on specific SLE plate) INTRODUCTION Solid-phase extraction (SPE) is a sample preparation technique by which compounds that are dissolved or suspended in a liquid matrix are extracted according to their physical and chemical properties. Reversed phase SPE sorbents can be either polymeric or silica based. In both cases, compounds are retained on the sorbent mainly by hydrophobic interactions. A washing step helps to remove matrix interferences. The analyte(s) can be eluted with an organic solvent, which disrupts the interaction of the analyte and the sorbent.1,2 Waters® Oasis PRiME HLB is a novel reversed phase SPE sorbent developed to enable simpler and faster SPE protocols, while at the same time generating cleaner extracts than other sample preparation methods with a simple, generic three step protocol.
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Alternate Webpage(s)	https://www.waters.com/webassets/cms/library/docs/720006060en.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article