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Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Novy, Patricia Huang, Xiaopei Leonard, Warren J. Yang, Yiping |
| Copyright Year | 2011 |
| Abstract | CD4 T cell help plays an important role in promoting CD8 T cell immunity to pathogens. In models of infection with vaccinia virus (VV) and Listeria monocytogenes, CD4 T cell help is critical for the survival of activated CD8 T cells during both the primary and memory recall responses. Still unclear, however, is how CD4 T cell help promotes CD8 T cell survival. In this study, we first showed that CD4 T cell help for the CD8 T cell response to VV infection was mediated by IL-21, a cytokine produced predominantly by activated CD4 T cells, and that direct action of IL-21 on CD8 T cells was critical for the VV-specific CD8 T cell response in vivo. We next demonstrated that this intrinsic IL-21 signaling was essential for the survival of activated CD8 T cells and the generation of long-lived memory cells. We further revealed that IL-21 promoted CD8 T cell survival in a mechanism dependent on activation of the STAT1 and STAT3 pathways and subsequent upregulation of the prosurvival molecules Bcl-2 and Bcl-x(L). These results identify a critical role for intrinsic IL-21 signaling in CD8 T cell responses to an acute viral infection in vivo and may help design effective vaccine strategies. |
| File Format | PDF HTM / HTML |
| DOI | 10.4049/jimmunol.1003009 |
| PubMed reference number | 21257966 |
| Journal | Medline |
| Volume Number | 186 |
| Issue Number | 5 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/186/5/2729.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.4049/jimmunol.1003009 |
| Journal | Journal of immunology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
