NDLI: IgA1 Glycosylation Is Heritable in Healthy Twins.

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IgA1 Glycosylation Is Heritable in Healthy Twins.

Content Provider	Semantic Scholar
Author	Lomax-Browne, Hannah J. Visconti, Alessia Pusey, Charles D. Cook, H. Terence Spector, Timothy David Pickering, Matthew C. Falchi, María Pía
Copyright Year	2017
Abstract	IgA nephropathy (IgAN) is the most common form of primary GN and an important cause of kidney failure. Characteristically, patients with IgAN have increased serum levels of undergalactosylated IgA1 (gd-IgA1). To assess the degree to which serum gd-IgA1 levels are genetically determined in healthy individuals, we determined serum IgA and gd-IgA1 levels by ELISA in a sample of 148 healthy female twins, including 27 monozygotic and 47 dizygotic pairs. Using the classic twin model, we found the heritability of serum gd-IgA1 and IgA levels to be 80% (95% confidence interval, 66% to 89%) and 46% (95% confidence interval, 15% to 69%), respectively. These data indicate that serum gd-IgA1 levels are highly heritable. Elucidating the genetic basis of this heritability will be important in understanding the pathogenesis of IgAN.
Starting Page	64
Ending Page	68
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.twinsuk.ac.uk/wp-content/uploads/2016/08/IgA1-Glycosylation-Is-Heritable-in-Healthy-Twins.pdf
Alternate Webpage(s)	https://kclpure.kcl.ac.uk/portal/files/53517897/Lomax_Browne.pdf
PubMed reference number	27313232v1
Alternate Webpage(s)	https://doi.org/10.1681/ASN.2016020184
DOI	10.1681/ASN.2016020184
Journal	Journal of the American Society of Nephrology : JASN
Volume Number	28
Issue Number	1
Language	English
Access Restriction	Open
Subject Keyword	Confidence Intervals Eighty Nine Enzyme-Linked Immunosorbent Assay Gadolinium DTPA IGA Glomerulonephritis Immunoglobulin A Kidney Diseases Kidney Failure Patients Sixty Nine
Content Type	Text
Resource Type	Article

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