The effects of neuroleptic medications on basal ganglia blood flow in schizophreniform disorders: a comparison between the neuroleptic-naïve and medicated states

Content Provider	Semantic Scholar
Author	Corson, Patricia Westmoreland Leary, Daniel S. O’ Miller, Del D. Andreasen, Nancy C.
Copyright Year	2002
Abstract	BACKGROUND Previous studies indicate that basal ganglia volumes of first-episode neuroleptic-naïve patients with schizophrenia are smaller than those of normal control subjects. Subsequent exposure to neuroleptic medication appears to induce volumetric change. Possible reasons for this include differences in blood flow and metabolism between the neuroleptic-naïve and medicated states. METHODS We used positron emission tomography (PET) to measure blood flow to the caudate and putamen, in a sample of 29 neuroleptic-naïve patients with schizophreniform disorders and 29 matched control subjects. We also studied a subset of the patient sample (n = 13), comparing their "before" versus "on" medication PET scans. RESULTS We did not find a significant difference in blood flow to the caudate and putamen between neuroleptic-naïve patients and control subjects even after controlling for whole brain blood flow; however, in the subset of 13 patients compared in the "on" versus "off" medication states, there was a statistically significant increase in blood flow to both the caudate and putamen. CONCLUSIONS Before treatment, there appears to be no difference in striatal blood flow between first-episode neuroleptic-naïve patients and healthy volunteers, but there appears to be a significant increase in blood flow to the striatum after the treatment is initiated.
Starting Page	855
Ending Page	862
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1016/S0006-3223(02)01421-X
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S000632230201421X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S000632230201421X?dgcid=api_sd_search-api-endpoint
PubMed reference number	12399138
Alternate Webpage(s)	https://doi.org/10.1016/S0006-3223%2802%2901421-X
Journal	Medline
Volume Number	52
Journal	Biological Psychiatry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article