La eficiencia del índice de PSA libre en el diagnóstico del cáncer de próstata

Content Provider	Semantic Scholar
Author	Ortiz, José Almoguer, Emilio
Copyright Year	2015
Abstract	Determining the efficiency of testing free PSA index in the diagnosis of prostate cancer. Design: Retrospective study. Location: Edgardo Rebagliati Martins National Hospital, EsSalud, Lima, Peru. Participants: Patients undergoing prostate biopsy. Interventions: Collection of data from 371 patients undergoing prostate biopsy -104 cases of prostate cancer and 267 cases of benign hyperplasia prostata-, by review of hospital medical records and review of pathological studies. Main outcome measures: Sensitivity, specificity, positive predictive value, negative predictive value, ROC curve (receiver operating characteristic) and area under the ROC curve (AUC) curve. Results: The rate of free PSA with the cutoff used in clinical practice of 0.20 showed a sensitivity of 0.85, specificity of 0.51, positive predictive value of 0.41, negative predictive value 0.90. The cutoff with a sensitivity of 0.95 was obtained 0.28. The area under the ROC curve was 0.78. Conclusions: The test demonstrated free PSA index improving the specificity of total PSA to avoid unnecessary biopsies. Be advisable to raise the cutoff of 0.20 used to increase the sensitivity of the test to 95%, to avoid the loss of detected cases of prostate cancer.
Starting Page	27
Ending Page	32
Page Count	6
File Format	PDF HTM / HTML
DOI	10.15381/anales.v76i1.11072
Volume Number	76
Alternate Webpage(s)	http://www.scielo.org.pe/pdf/afm/v76n1/a05v76n1.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article