The association of vitamin D deficiency with non-alcoholic fatty liver disease

Content Provider	Semantic Scholar
Author	Küçükazman, Metin Ata, Naim Dal, Kürşat Yeniova, Abdullah Özgür Kefeli, Ayşe Başyiğit, Sebahat Aktaş, Bora Akin, Kadir Okhan Ağladioğlu, Kadir Üre, Öznur Sari Topal, Firdes Nazligül, Yaşar Beyan, Eśin Ertuğrul, Derun Taner
Copyright Year	2014
Abstract	OBJECTIVE Vitamin D deficiency has been related to diabetes, hypertension, hyperlipidemia and peripheral vascular disease. In this study, we aimed to investigate the role of vitamin D status in non-alcoholic fatty liver disease. METHODS We included 211 consecutive subjects to examine the presence of non-alcoholic fatty liver disease. Of these subjects, 57 did not have non-alcoholic fatty liver disease and 154 had non-alcoholic fatty liver disease. RESULTS The non-alcoholic fatty liver disease group had significantly higher fasting blood glucose (p = 0.005), uric acid (p = 0.001), aspartate aminotransferase (p<0.001), alanine aminotransferase (p<0.001), γ-glutamyltransferase (p<0.0001), alkaline phosphatase (p = 0.028), HbA1c (p<0.001), ferritin (p<0.001), insulin (p = 0.016), C-peptide (p = 0.001), HOMA-IR (p = 0.003), total cholesterol (p = 0.001), triglyceride (p = 0.001) and white blood cell (p = 0.04) levels. In contrast, the non-alcoholic fatty liver disease group had significantly lower 25(OH)D levels (12.3±8.9 ng/dl, p<0.001) compared with those of the control group (20±13.6 ng/dl). CONCLUSIONS In this study, we found lower serum 25(OH)D levels in patients with non-alcoholic fatty liver disease than in subjects without non-alcoholic fatty liver disease. To establish causality between vitamin D and non-alcoholic fatty liver disease, further interventional studies with a long-term follow-up are needed.
Starting Page	542
Ending Page	546
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.clinics.org.br/uploads/artigos/cln-69-08/cln-69-08-542.pdf
PubMed reference number	25141113
Volume Number	69
Journal	Clinics
Language	English
Access Restriction	Open
Subject Keyword	Alanine Alcoholics Alkaline Phosphatase Aspartate Transaminase Aspartic Acid Blood Cells C-Peptide Cholesterol D Vitamin Diabetes Mellitus Fatty Liver, Alcoholic Glucose Hematological Disease Hyperlipidemia Hypertensive disease Leukocytes Long-term Follow-up Nanogram per Deciliter Non-alcoholic Fatty Liver Disease Patients Peripheral Vascular Diseases Steatohepatitis Transaminases Triglycerides Uric Acid Vitamin D Deficiency
Content Type	Text
Resource Type	Article