El pretratamiento con alopurinol disminuye la translocación bacteriana y atenúa los cambios morfológicos de la mucosa intestinal en un modelo de isquemia-reperfusión intestinal en ratas

Content Provider	Semantic Scholar
Author	Riveros, E. Maria Elena Pérez, Iván Becerra, Karen Bustamante, Manuel Millán, Cristina Manrique, Fred Gustavo
Copyright Year	2012
Abstract	Objective: To evaluate the protective effect of pretreatment with allopurinol in an intestinal ischemia-reperfusion injury rat model. Materials and methods: A controlled animal trial was conducted; 10 Wistar rats were kept under controlled conditions for three days. One group (n=5) received allopurinol 50 mg/kg per day for the 3-day period and an additional dose immediately prior to surgical mesenteric artery clamping (60 minutes) and reperfusion (60 minutes). The other group (n=5) did not receive the medication. Hystologic analysis of intestinal mucosa by means of Chou grading system was performed, and blood cultures from the heart were withdrawn. Results: Positive blood cultures were found in 20% of the allopurinol group as compared with 100% in the control group (p<0.0001). Deep mucosal lesion was evidence in all cases. Allopurinol pretreatment reduced significantly the ischemia-reperfusion injury (p<0.001). Conclusions: Allopurinol administration prior to intestinal ischemia ameliorated morphologic changes related to the ischemia-reperfusion process. The beneficial effect of allopurinol was demonstrated with pretreatment for three days.
Starting Page	227
Ending Page	234
Page Count	8
File Format	PDF HTM / HTML
Volume Number	27
Alternate Webpage(s)	http://www.scielo.org.co/pdf/rcci/v27n3/v27n3a8.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article