NDLI: IL-18 modulates chronic fungal asthma in a murine model; putative involvement of Toll-like receptor-2

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IL-18 modulates chronic fungal asthma in a murine model; putative involvement of Toll-like receptor-2

Content Provider	Semantic Scholar
Author	Blease, Kate Kunkel, Steven L. Hogaboam, Cory M.
Copyright Year	2001
Abstract	Abstract. Fungus-induced asthmatic disease is characterized by persistent airway hyperreactivity and remodeling.¶Objective and design: To determine the role of IL-18 in the allergic airway response to Aspergillus fumigatus conidia in a murine model of A. fumigatus-induced asthma.¶Methods:A. fumigatus-sensitized mice were depleted of IL-18 using a polyclonal anti-IL-18 antibody for 3 days after a conidia challenge.¶Results: Airway hyperresponsiveness and eosinophil numbers were significantly elevated 3-30 days after conidia challenge compared to the normal serum-treated group. Histological evidence showed retention of A. fumigatus conidia, airway remodeling, subepithelial fibrosis, and increased collagen deposition in the lungs of IL-18-depleted mice at day 30 after the conidia challenge. Prolonged retention of conidia in IL-18 depleted A. fumigatus-sensitized mice was associated with decreased Toll-like receptor-2 (TLR-2) expression compared with the control group.¶Conclusions: IL-18 modulates the innate immune response against A. fumigatus conidia and prevents the development of severe fungus-induced asthmatic disease.
Starting Page	552
Ending Page	560
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1007/PL00000233
Alternate Webpage(s)	https://deepblue.lib.umich.edu/bitstream/handle/2027.42/41823/11-50-11-552_10500552.pdf;jsessionid=CA21D1F37851402B5DD9102221CF5F95?sequence=1
PubMed reference number	11766995
Alternate Webpage(s)	https://doi.org/10.1007/PL00000233
Journal	Medline
Volume Number	50
Journal	Inflammation Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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