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Asymmetric Palladium-Catalyzed Directed Intermolecular Fluoroarylation of Styrenes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Talbot, Eric P. A. Fernandes, Talita Almeida McKenna, Jeffrey M. Toste, F. Dean |
| Copyright Year | 2014 |
| Abstract | A mild catalytic asymmetric direct fluoro-arylation of styrenes has been developed. The palladium-catalyzed three-component coupling of Selectfluor, a styrene and a boronic acid, provides chiral monofluorinated compounds in good yield and in high enantiomeric excess. A mechanism proceeding through a Pd(IV)-fluoride intermediate is proposed for the transformation and synthesis of an sp(3) C-F bond. |
| Starting Page | 4101 |
| Ending Page | 4104 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/ja412881j |
| PubMed reference number | 24617344 |
| Journal | Medline |
| Volume Number | 136 |
| Alternate Webpage(s) | http://www.cchem.berkeley.edu/toste/publications/ja412881j.pdf |
| Alternate Webpage(s) | http://www.cchem.berkeley.edu/~toste/publications/ja412881j.pdf |
| Journal | Journal of the American Chemical Society |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |