NDLI: Comparative Binding Affinities of Flavonoid Phytochemicals with Bovine Serum Albumin

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Comparative Binding Affinities of Flavonoid Phytochemicals with Bovine Serum Albumin

Content Provider	Semantic Scholar
Author	Liu, Shuqing Guo, Chunmei Guo, Yimeng Yu, Hongshan Greenaway, Frederick T. Sun, Ming-Zhong
Copyright Year	2014
Abstract	Dietary flavonoids show beneficial effects in the prevention of chronic diseases. However, flavonoid bioavailability is poor, probably due to their interaction with serum albumins. In the current work, the binding interactions of eight related flavonoids, sharing a similar core structure, with bovine serum albumin (BSA) were investigated by fluorescence spectroscopy. The binding affinities of the flavonoids with BSA were in the order hesperetin (KA=5.59 × 10(5))> quercetin (4.94 × 10(5)) > naringenin (3.04 × 10(5)) > isoquercitrin (4.66 × 10(4)) > icariin (3.60 × 10(4)) > rutin (1.65 × 10(4)) > hesperidin (2.50 × 10(3)) > naringin (8.70 × 10(2)). The associations of specific structural components of the flavonoids with their binding properties to BSA were also explored and hydrophobicity, functional group substituents, steric hindrance effects and the spatial arrangements of substituents seem to be the key factors for the affinities of flavonoids towards BSA. The results from the current work contribute to a better understanding of the transport of flavonoids in plasma and helping predict their physiological functions based on their intrinsic structures.
Starting Page	1019
Ending Page	1028
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ijpr.sbmu.ac.ir/article_1558_4ca9d159a2a8d63a054027daa05b7b5a.pdf
PubMed reference number	25276204
Volume Number	13
Journal	Iranian journal of pharmaceutical research : IJPR
Language	English
Access Restriction	Open
Subject Keyword	Albumins Bos taurus Chronic disease Flavonoids Fluorescence Spectroscopy Hesperidin Mental association Phytochemicals Quercetin Rutin Serum Albumin Serum Albumin, Bovine flavonoid 3'-hydroxylase activity hesperetin icariin isoquercitrin naringenin naringin
Content Type	Text
Resource Type	Article

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