Loading...
Please wait, while we are loading the content...
Similar Documents
Chiral Brønsted Acid-Catalyzed Metal-Free Asymmetric Direct Reductive Amination Using 1-Hydrosilatrane.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Skrypai, Vladislav Varjosaari, Sami E. Azam, Fawwaz Gilbert, Thomas M. Adler, Marc J. |
| Copyright Year | 2019 |
| Abstract | The asymmetric direct reductive amination of prochiral ketones with aryl amines using 1-hydrosilatrane with a chiral Brønsted acid catalyst is reported. This is the first known example of chiral Brønsted acid-catalyzed asymmetric reductive amination using a silane as the hydride source. The reaction features a highly practical reducing reagent and proceeds efficiently at room temperature without a specialized reaction setup or equipment to exclude air or moisture. This method provides high conversion and enantiomeric excess up to 84% of the desired chiral secondary amines with minimal side products. |
| Starting Page | 5021 |
| Ending Page | 5026 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/acs.joc.8b03073 |
| Alternate Webpage(s) | https://static1.squarespace.com/static/59e3dad18c56a8a04e1106c1/t/5d2d1ecad83c2900011e6a28/1563238093797/2019+JOC.pdf |
| PubMed reference number | 30973732 |
| Alternate Webpage(s) | https://doi.org/10.1021/acs.joc.8b03073 |
| Journal | Medline |
| Volume Number | 84 |
| Issue Number | 9 |
| Journal | The Journal of organic chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
