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Inhibition of haem-iron absorption in man by calcium.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hallberg, Lillemor Rossander-Hulthén, Lena Brune, Mats Gleerup, Ann |
| Copyright Year | 1993 |
| Abstract | The inhibiting effect of Ca on non-haem-Fe absorption is well established. Present studies showed that Ca inhibited haem-Fe absorption to the same extent when the same amount of Ca (165 mg Ca as CaCl2) was added to a meal. Attempts were made to examine the mechanism for this inhibition in the present studies. Meat is the only known dietary factor influencing haem-Fe absorption. The present studies were designed to examine whether Ca interfered with the enhancing effect of meat on haem-Fe absorption. We found that the inhibition was the same whether biosynthetically radio-Fe-labelled haemoglobin was given in meals with or without meat. The haem-Fe absorption ratio with:without added Ca was 0.59 (SE 0.07) when Ca was added to a hamburger meal, and 0.52 (SE 0.03) when added to a wheat roll. These values were not significantly different (t 0.95; P = 0.35). The inhibition of haem-Fe absorption by Ca is, thus, a direct effect on the absorption of haem-Fe and not an indirect counteracting effect of the well-known enhancing effect of meat on haem-Fe absorption. Control studies were conducted to ensure that haem-Fe had not been degraded to non-haem-Fe during preparation of the foods. Since Ca inhibits the absorption of haem- and non-haem-Fe to the same extent, the present results strongly suggest that Ca interferes with the transport of Fe through the mucosal cell, and at a late stage, is common for haem- and non-haem-Fe transport.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Starting Page | 217 |
| Ending Page | 220 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/9E31FD80E74E449DEF9D5B2186DB4DBC/S0007114593000546a.pdf/inhibition_of_haemiron_absorption_in_man_by_calcium.pdf |
| Alternate Webpage(s) | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114593000546 |
| PubMed reference number | 8490006v1 |
| Volume Number | 69 |
| Issue Number | 2 |
| Journal | The British journal of nutrition |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Calcium Dietary Iron Food Heme Hemoglobin Inhibition Meal (occasion for eating) Mucous Membrane Status Epilepticus |
| Content Type | Text |
| Resource Type | Article |
