NDLI: Superoxide dismutase SOD-1 modulates C. elegans pathogen avoidance behavior

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Superoxide dismutase SOD-1 modulates C. elegans pathogen avoidance behavior

Content Provider	Semantic Scholar
Author	Horspool, Alexander M. Chang, Howard Chia-Hao
Copyright Year	2017
Abstract	The C. elegans nervous system mediates protective physiological and behavioral responses amid infection. However, it remains largely unknown how the nervous system responds to reactive oxygen species (ROS) activated by pathogenic microbes during infection. Here, we show superoxide dismutase-1 (SOD-1), an enzyme that converts superoxide into less toxic hydrogen peroxide and oxygen, functions in the gustatory neuron ASER to mediate C. elegans pathogen avoidance response. When C. elegans first encounters pathogenic bacteria P. aeruginosa, SOD-1 is induced in the ASER neuron. After prolonged P. aeruginosa exposure, ASER-specific SOD-1 expression is diminished. In turn, C. elegans starts to vacate the pathogenic bacteria lawn. Genetic knockdown experiments reveal that pathogen-induced ROS activate sod-1 dependent behavioral response non cell-autonomously. We postulate that the delayed aversive response to detrimental microbes may provide survival benefits by allowing C. elegans to temporarily utilize food that is tainted with pathogens as an additional energy source. Our data offer a mechanistic insight into how the nervous system mediates food-seeking behavior amid oxidative stress and suggest that the internal state of redox homeostasis could underlie the behavioral response to harmful microbial species.
Starting Page	1
Ending Page	19
Page Count	19
File Format	PDF HTM / HTML
PubMed reference number	28322326v1
Alternate Webpage(s)	https://doi.org/10.1038/srep45128
DOI	10.1038/srep45128
Journal	Scientific reports
Volume Number	7
Language	English
Access Restriction	Open
Subject Keyword	Activation action CNS disorder Host-Pathogen Interactions Hydrogen Peroxide Neurons Oxidative Stress Pathogenic organism Peroxides Pseudomonas aeruginosa Ab:ACnc:Pt:Ser:Qn RBFOX2 gene REM Sleep Behavior Disorder Reactive Oxygen Species Superoxides benefit mab-20 protein, C elegans superoxide dismutase 1 superoxide dismutase activity
Content Type	Text
Resource Type	Article

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