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In Vitro Release of Cisplatin from Biodegradable Poly ( Dl-lactic-co-glycolic Acid ) Microsphere Vehicles
| Content Provider | Semantic Scholar |
|---|---|
| Copyright Year | 2005 |
| Abstract | INTRODUCTION: Cisplatin, alone or in combination with other chemotherapeutic drugs, is currently in clinical use for patients with osteosarcoma. However, the frequent occurrence of systemic toxicity, especially nephroand neuro-toxicity, limits its dose in these patients. Localized controlled delivery of the drug to the tumor would decrease systemic cisplatin levels and possibly result in higher local doses. Additionally, the development of a biodegradable vehicle containing a depot dose of cisplatin would improve local treatment options that otherwise require drug loaded non-degradable beads and repeat surgery for their removal. The goal of this study is to investigate the in vitro release of cisplatin from biodegradable microsphere vehicles and evaluate their efficacy against an osteosarcoma cell line. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ors.org/Transactions/52/0928.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
