NDLI: Electrospun polyvinyl alcohol-collagen-hydroxyapatite nanofibers: a biomimetic extracellular matrix for osteoblastic cells.

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Electrospun polyvinyl alcohol-collagen-hydroxyapatite nanofibers: a biomimetic extracellular matrix for osteoblastic cells.

Content Provider	Semantic Scholar
Author	Song, Wei Markel, David C. Wang, Sunxi Shi, Tong Mao, Guangzhao Ren, Weiping
Copyright Year	2012
Abstract	The failure of prosthesis after total joint replacement is due to the lack of early implant osseointegration. In this study polyvinyl alcohol-collagen-hydroxyapatite (PVA-Col-HA) electrospun nanofibrous meshes were fabricated as a biomimetic bone-like extracellular matrix for the modification of orthopedic prosthetic surfaces. In order to reinforce the PVA nanofibers, HA nanorods and Type I collagen were incorporated into the nanofibers. We investigated the morphology, biodegradability, mechanical properties and biocompatibility of the prepared nanofibers. Our results showed these inorganic-organic blended nanofibers to be degradable in vitro. The encapsulated nano-HA and collagen interacted with the PVA content, reinforcing the hydrolytic resistance and mechanical properties of nanofibers that provided longer lasting stability. The encapsulated nano-HA and collagen also enhanced the adhesion and proliferation of murine bone cells (MC3T3) in vitro. We propose the PVA-Col-HA nanofibers might be promising modifying materials on implant surfaces for orthopedic applications.
Starting Page	115101
Ending Page	115101
Page Count	1
File Format	PDF HTM / HTML
DOI	10.1088/0957-4484/23/11/115101
PubMed reference number	22370251
Journal	Medline
Volume Number	23
Issue Number	11
Alternate Webpage(s)	http://www.eng.wayne.edu/user_files/139/file/Quick_Upload/0957-4484_23_11_115101.pdf
Alternate Webpage(s)	https://doi.org/10.1088/0957-4484%2F23%2F11%2F115101
Journal	Nanotechnology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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