NDLI: Leukotriene D4 is a mediator of proteinuria and glomerular hemodynamic abnormalities in passive Heymann nephritis.

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Leukotriene D4 is a mediator of proteinuria and glomerular hemodynamic abnormalities in passive Heymann nephritis.

Content Provider	Semantic Scholar
Author	Katoh, Tetsuo Lianos, Elias A. Fukunaga, Masahiro Takahashi, Kenzo Badr, Kamal F.
Copyright Year	1993
Abstract	We assessed the role of leukotrienes (LTs) in Munich-Wistar rats with passive Heymann nephritis (PHN), an animal model of human membranous nephropathy. 10 d after injection of anti-Fx1A antibody, urinary protein excretion rate (Upr) in PHN was significantly higher than that of control. Micropuncture studies demonstrated reduced single nephron plasma flow and glomerular filtration rates, increased transcapillary hydraulic pressure difference, pre- and postglomerular resistances, and decreased ultrafiltration coefficient in PHN rats. Glomerular LTB4 generation from PHN rats was increased. Administration of the 5-LO activating protein inhibitor MK886 for 10 d markedly blunted proteinuria and normalized glomerular hemodynamic abnormalities in PHN rats. An LTD4 receptor antagonist SK&F 104353 led to an immediate reduction in Upr and to reversal of glomerular hemodynamic impairment. Ia(+) cells/glomerulus were increased in PHN rats. In x-irradiated PHN rats, which developed glomerular macrophage depletion, augmented glomerular LT synthesis was abolished. Thus, in the autologous phase of PHN, LTD4 mediates glomerular hemodynamic abnormalities and a hemodynamic component of the accompanying proteinuria. The synthesis of LTD4 likely occurs directly from macrophages or from macrophage-derived LTA4, through LTC4 synthase in glomerular cells.
Starting Page	795
Ending Page	803
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/116000/116356/JCI93116356.pdf
PubMed reference number	8386188v1
Volume Number	91
Issue Number	4
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Subject Keyword	Arachidonate 5-Lipoxygenase Coefficient Congenital Abnormality Glomerular Filtration Rate Hemodynamics Heymann Nephritis Kidney Diseases Kidney Glomerulus Leukotriene A4 Leukotriene Antagonists Leukotriene B4 Leukotriene C4 Leukotriene D4 Leukotrienes Mediator brand of benfluorex hydrochloride Membranous glomerulonephritis Micropunctures Nephrons Postherpetic neuralgia Tissue membrane Total Protein Urine Excretion Rate Ultrafiltration (procedure) cellular response to unfolded protein
Content Type	Text
Resource Type	Article

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