NDLI: Why Do We Need New Anti-hiv Drugs ?

Content Provider	Semantic Scholar
Author	Bean, Pamela W.
Copyright Year	2005
Abstract	A significant number of human immunodeficiency virus (HIV) infections have become resistant to antiretroviral treatment, which means that there is a paramount need for novel drug targets to defeat the virus. Until recently, all HIV drugs inhibited HIV replication by mechanisms operating inside infected cells. In contrast, new antiretroviral drugs operate outside infected cells. Their mechanism of action consists in inhibiting entry of the virus into cells, thereby halting the very first step of HIV replication. Examples of this new class of drugs include entry inhibitors, coreceptor antagonists, and fusion inhibitors. In addition to their novel mechanism of action, this new class of drugs also has potential action against drug-resistant HIV strains, causes minimal adverse effects, and may be administered in a simplified, once-daily dosing regimen. New classes of anti-HIV drugs—and new drugs in existing classes—represent the best hope for people infected with HIV, especially those who have exhausted current therapies.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/cid/41/Supplement_1/10.1086/429504/2/41-Supplement_1-S96.pdf?Expires=1492562901&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=LAtnyYsv~8w7GjYtuNfxPT5eGvoeKfBA2PiolXpDyNI5x9iZvCHcPQhdu0Vgvktl1t-eFzYqowRoEi1084j27cvnMjX7qpY66bBN8SbAfxOeMG30hjZ5xFA4wfCtSvOdd6Ct1gZ8uZggGwSJzFwhYdmChyb4VAZt-O7OZRVcYrYwWwgxZcO1Vfbwkr6rKU~sYGx55Mg8cbQDaW1z78vV7cDk88RWLl-j-WwmCwaHzNtIsBJnX-Mr2d3LVIoBY0XNINtl0688C43D5Bd~e3MIlhhLgB-5ZW001KxwPUD6eAt-Tc5Q43ya~MEIqo0nb4~gMcFzKn8s8wzpIXd5vQ0r4Q__
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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