NDLI: Self-assembled monolayers of bifunctional periodic mesoporous organosilicas for cell adhesion and cellular patterning

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Self-assembled monolayers of bifunctional periodic mesoporous organosilicas for cell adhesion and cellular patterning

Content Provider	Semantic Scholar
Author	Benson, Kathrin Prasetyanto, Eko Adi Galla, Hans-Joachim Kehr, Nermin Seda
Copyright Year	2012
Abstract	Periodic mesoporous organosilicas (PMOs), an important class of inorganic–organic functional hybrid materials, find numerous potential applications in nano- and biotechnologies due to their porous nature, large surface area (internal and external surfaces) and the structural diversity of their organosilica frameworks. In this contribution we report on the selective functionalization of both the internal and the external surfaces of PMOs with a fluorescent dye and bioactive molecules, respectively. Subsequently we used these unique bifunctionalized PMO nanoparticles for the preparation of non-patterned and patterned self-assembled monolayers (SAMs) on glass. In cell experiments we showed that these new biomaterial surfaces enhance cell adhesion. We were able to determine the position of the inside dye substituted PMOs of the biomolecule functionalized surface in relation to the position of the stained cells by fluorescence microscopy as well. Patterned SAMs of bifunctionalized PMOs lead to selective cellular patterning along the stripes (texture of the surface).
Starting Page	10845
Ending Page	10852
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1039/C2SM26563J
Volume Number	8
Alternate Webpage(s)	http://www.rsc.org/suppdata/sm/c2/c2sm26563j/c2sm26563j.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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