NDLI: Synthesis of Pyrimidine Incorporated Piperazine Derivatives and their Antimicrobial Activity

Please wait, while we are loading the content...

Synthesis of Pyrimidine Incorporated Piperazine Derivatives and their Antimicrobial Activity

Content Provider	Semantic Scholar
Author	Thriveni, K. S. Padmashali, Basavaraj Siddesh, M. B. Sandeep, Cuddapah
Copyright Year	2014
Abstract	Thiophene substituted chalcones (1a-e) were cyclised with thiourea in presence of potassium hydroxide to get 4-substituted-6-(thiophen-2-yl)pyrimidine-2-thiols (2a-e) which were then stirred with methyl iodide to obtain 4-substituted-2-(methylsulfanyl)-6-(thiophen-2-yl)pyrimidines (3a-e). Compounds (3a-e) were refluxed with different N-methylpiperazine and N-phenylpiperazine to afford 4-substituted-2-(4-methylpiperazin-1-yl)-6-(thiophen-2-yl)pyrimidines (4a-e) and 4-substituted-2-(4-phenylpiperazin-1-yl)-6-(thiophen-2-yl)pyrimidines (5a-e). The structures of all the newly synthesised compounds 4b, 4d, 5a and 5b showed good antibacterial activity at 40μg/mlconcentration. Compounds 4a, 4d, 4e, 5c and 5e showed significant antifungal activity at 40 μg/ml concentration compared with standard drugs.
Starting Page	332
Ending Page	338
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.ijpsonline.com/articles/synthesis-of-pyrimidine-incorporated-piperazine-derivatives-and-their-antimicrobial-activity.pdf
PubMed reference number	25284931
Volume Number	76
Journal	Indian journal of pharmaceutical sciences
Language	English
Access Restriction	Open
Subject Keyword	Anti-Bacterial Agents Antifungal Agents Chalcone Dimethylphenylpiperazinium Iodide Hydroxide Ion Iodides Maxillary right first molar abutment Maxillary right first premolar abutment Maxillary right second premolar abutment Potassium Hydroxide Pyrimidines Reflux Thiourea alphanumeric label - 1A methyl iodide piperazine
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in