NDLI: The perils of rational design--unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S).

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The perils of rational design--unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S).

Content Provider	Semantic Scholar
Author	Yevglevskis, Maksims Lee, Guat Ling Threadgill, Michael D. Woodman, Timothy J. Lloyd, Matthew D.
Copyright Year	2014
Abstract	α-Methylacyl-CoA racemase (AMACR; P504S) catalyses 'racemization' of 2-methylacyl-CoAs, the activation of R-ibuprofen and is a promising cancer drug target. Human recombinant AMACR 1A catalyses elimination of 3-fluoro-2-methyldecanoyl-CoAs to give E-2-methyldec-2-enoyl-CoA and fluoride anion, a previously unknown reaction. 'Racemization' of 2-methyldec-3-enoyl-CoAs was also catalysed, without double bond migration.
File Format	PDF HTM / HTML
DOI	10.1039/c4cc06127f
Alternate Webpage(s)	https://purehost.bath.ac.uk/ws/portalfiles/portal/112735163/Accepted_version.pdf
Alternate Webpage(s)	https://pubs.rsc.org/en/content/getauthorversionpdf/C4CC06127F
Alternate Webpage(s)	http://www.rsc.org/suppdata/cc/c4/c4cc06127f/c4cc06127f1.pdf
Alternate Webpage(s)	https://purehost.bath.ac.uk/ws/portalfiles/portal/112735164/Supplemental_information.pdf
PubMed reference number	25277991
Alternate Webpage(s)	https://doi.org/10.1039/c4cc06127f
Journal	Medline
Volume Number	50
Issue Number	91
Journal	Chemical communications
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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