NDLI: Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.

Content Provider	Semantic Scholar
Author	Kang, Angray S. Barbas, Carlos F. Janda, Kim D. Benkovic, Stephen J. Lerner, Richard A.
Copyright Year	1991
Abstract	We describe a method based on a phagemid vector with helper phage rescue for the construction and rapid analysis of combinatorial antibody Fab libraries. This approach should allow the generation and selection of many monoclonal antibodies. Antibody genes are expressed in concert with phage morphogenesis, thereby allowing incorporation of functional Fab molecules along the surface of filamentous phage. The power of the method depends upon the linkage of recognition and replication functions and is not limited to antibody molecules.
File Format	PDF HTM / HTML
DOI	10.1073/pnas.88.10.4363
PubMed reference number	1903540
Journal	Medline
Volume Number	88
Issue Number	10
Alternate Webpage(s)	https://www.scripps.edu/barbas/pdf/PNASKang1991.pdf
Alternate Webpage(s)	https://doi.org/10.1073/pnas.88.10.4363
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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