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Polypharmacy and Adverse Drug Events Leading to Acute Care Hospitalization in Japanese Elderly
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fushiki, Yoko Kinoshita, Kensuke Tokuda, Yasuharu |
| Copyright Year | 2014 |
| Abstract | Results: The mean age was 79.5 years (men, 54%). The mean number of medications was 6.36 +/1 4.15 (maximum, 26). Polypharmacy was observed in 63% of cases. ADEs were identified in 4.9% (95% CI, 3.5–6.7%). The mean numbers of medications among patients with ADEs and those without ADEs were 9.3 +/1 3.4 and 6.2 +/1 4.1, respectively. A greater number of medications was significantly associated with ADEs (p < 0.001). Polypharmacy was identified in 91% of patients with ADEs, while it was noted in 62% of patients without ADEs (p = 0.001). Using logistic regression analysis, polypharmacy was significantly associated with ADEs (Odds ratio 5.89, 95% CI 1.74– 19.9). The highest number of ADEs were identified among patients on antiplatelets or anticoagulants (n = 8), followed by benzodiazepines and NSAIDs (n = 4 for both). The most common ADEs were gastrointestinal bleeding, nausea and congestive heart failure. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/general/15/2/15_110/_pdf/-char/ja |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adverse reaction to drug Anti-Inflammatory Agents, Non-Steroidal Anticoagulants Benzodiazepines Emoticon Gastrointestinal Hemorrhage Heart failure Logistic regression Nausea Patients Windows 95 |
| Content Type | Text |
| Resource Type | Article |
