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Duraflo ? II heparin treated extracorporeal circulation circuits ( 2 nd version ) the European working group on heparin coated extracorporeal circulation circuits
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wildevuur, R. H. Jansen, Piet G. M. Bezemer, Pieter D. Kuik, Dirk J. Eijsman, Léon Bruins, Peter Jong, A. P. De Hardevelt, F. W. J. Van Biervliet, Jules D. Hasenkam, J. Michael Kure, H-H. Knudsen, L. Bellaiche, L. Ahlburg, P. Loisance, Daniel Y. Baufreton, Christophe Besnerais, Paul Le Bajan, G. Matta, Anand Dyck, Maria Van Renotte, M. T. Ponlot-Lois, A. Baele, Ph. Mcgovern, E. McCarthy, J. McCarthy, Affrica O'donnell, A. R. Fosse, Einar Moen, Oddmar Dregelid, Einar Brockmeier, V. Anderson, Chris Pomar, José Luís Ranucci, Marco Conti, David V. Cirri, Silvia Conti, Ettore Ditta, Antonio Segesser, Ludwig K. Von Tkebuchava, Tengiz Weiss, Brendan M. Turina, Marku I. Svennevig, Jan Mohr, Benno Videm, Vibeke Karlsen, Henning Pedersen, T. H. Thelin, Stefan Haldén, E. Hagman, L. Thörnö, E. Ahlvin, Eric Corvallis |
| Copyright Year | 1997 |
| Abstract | Objectives: To evaluate whether the application of heparin treated circuits for elective coronary artery surgery improves postoperative recovery, a European multicenter randomised clinical trial was carried out. Methods: In 11 European heart centers, 805 low-risk patients underwent cardiopulmonary bypass (CPB) with either an untreated circuit (n=407) or an identical but heparin treated circuit (n=398, DurafloII). Results: Significant differences were found among participating centers with respect to patient characteristics, blood handling procedures and postoperative care. The use of heparin treated circuits revealed no overall changes in blood loss, blood use, time on ventilator, occurrence of adverse events, morbidity, mortality, and intensive care stay. These results did not change after adjustment for centers and (other) prognostic factors as analysed with logistic regression. In both groups no clinical or technical (patient or device related) side effects were reported. Because female gender and aortic * Corresponding author. The European Working Group on heparin coated extracorporeal circulation circuits, P.O. Box 169, 5400 AD Uden, Netherlands. Tel.: +31 413 286621; fax +31 413 250085. 1010-7940/97/$17.00 © 1997 Elsevier Science B.V. All rights reserved. PII S 1 0 10 -7940 (96 )01122 -0 C.R.H. Wilde6uur et al. / European Journal of Cardio-thoracic Surgery 11 (1997) 616–623 617 cross clamp time appeared as prognostic factors in the logistic regression analysis, a subgroup analysis with these variables was performed. In a subpopulation of females (n=99), those receiving heparin treated circuits needed less blood products, had a lower incidence of rhythm disturbances and were extubated earlier than controls. In another subgroup of patients with aortic cross clamp time exceeding 60 min (n=197), the amount of patients requiring prolonged intensive care treatment (\24 h) was significantly lower when they received heparin treated circuits versus controls. Conclusion: These findings suggest that improved recovery can be expected with heparin treated circuits in specific higher risk patient populations (e.g. females) and when prolonged aortic cross clamp time is anticipated. Further investigations are recommended to analyse the clinical benefit of heparin treated circuits in studies with patients in different well defined risk categories and under better standardised circumstances. © 1997 Elsevier Science B.V. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://pure.uva.nl/ws/files/3242062/2729_26068y.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
