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Antiepileptic effect of antiepilepsirine in pentylenetetrazol and amygdala kindled rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Li Vieth, Robert F. Landes, Robert C. Suzuki, Yasuhiro Walson, Philip D. |
| Copyright Year | 1993 |
| Abstract | Antiepilepsirine (AES) is a new antiepileptic drug developed in China. Anticonvulsant effects of AES were studied in both pentylenetetrazol (PTZ, n = 20) and amygdala kindled (n = 10) rats. AES was given once per day by oral gavage for 4 weeks. On days 7, 14, 21 and 28, all rats were tested 2 h after daily AES administration: PTZ and amygdala kindled rats were given a PTZ injection (30 mg/kg, i.p.) or amygdala stimulation (400 microA, 1 s), respectively. Behavior was observed, and seizures were graded. AES (300 or 500 mg/kg) produced sustained, dose dependent, protective effects against PTZ induced seizures in PTZ kindled rats, while AES (500 mg/kg) had no effects in amygdala kindled rats. |
| Starting Page | 1 |
| Ending Page | 5 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0920-1211(93)90002-O |
| PubMed reference number | 8325273 |
| Journal | Medline |
| Volume Number | 15 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/092012119390002O |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/092012119390002O?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0920-1211%2893%2990002-O |
| Journal | Epilepsy Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
