Relationship between quantitative and descriptive methods of studying blood flow through intrapulmonary arteriovenous anastomoses during exercise

Content Provider	Semantic Scholar
Author	Duke, Joseph W. Elliott, Jonathan E. Laurie, Steven S. Voelkel, Thomas Lovering, Andrew T.
Copyright Year	2017
Abstract	Several methods exist to study intrapulmonary arteriovenous anastomoses (IPAVA) in humans. Transthoracic saline contrast echocardiography (TTSCE), i.e., bubble scores, is minimally-invasive, but cannot be used to quantify the magnitude of blood flow through IPAVA (QIPAVA). Radiolabeled macroaggregates of albumin (99mTc-MAA) have been used to quantify QIPAVA in humans, but this requires injection of radioactive particles. Previous work has shown agreement between 99mTc-MAA and TTSCE, but this has not been tested simultaneously in the same group of subjects. Thus, the purpose of this study was to determine if there was a relationship between QIPAVA quantified with 99mTc-MAA and bubble scores obtained with TTSCE. To test this, we used 99mTc-MAA and TTSCE to quantify and detect QIPAVA at rest and during exercise in humans. QIPAVA significantly increased from rest to exercise using 99mTc-MAA and TTSCE and there was a moderately-strong, but significant relationship between methods. Our data suggest that high bubble scores generally correspond with large QIPAVA quantified with 99mTc-MAA during exercise.
Starting Page	47
Ending Page	54
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1016/j.resp.2017.05.006
PubMed reference number	28536067
Journal	Medline
Volume Number	243
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S156990481730023X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S156990481730023X?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.resp.2017.05.006
Journal	Respiratory Physiology & Neurobiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article