NDLI: Peripheral macrophage recruitment in cuprizone-induced CNS demyelination despite an intact blood

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Peripheral macrophage recruitment in cuprizone-induced CNS demyelination despite an intact blood–brain barrier

Content Provider	Semantic Scholar
Author	McMahon, Eileen J. Suzuki, Kinuko Matsushima, Glenn K.
Copyright Year	2002
Abstract	The contribution of peripheral macrophage was assessed in cuprizone intoxication, a model of demyelination and remyelination in which the blood-brain barrier remains intact. Flow cytometry of brain cells isolated from cuprizone-treated mice revealed an increase in the percentage of Mac-1(+)/CD45(hi) peripheral macrophage. To confirm these results in situ, C57BL/6 mice were lethally irradiated, transplanted with bone marrow from GFP-transgenic mice, and exposed to cuprizone. GFP(+) peripheral macrophages were seen in the CNS after 2 weeks of treatment, and infiltration continued through 6 weeks. While the peripheral macrophages were far outnumbered by the resident microglia, their recruitment across the blood-brain barrier alludes to a potentially important role.
Starting Page	32
Ending Page	45
Page Count	14
File Format	PDF HTM / HTML
DOI	10.1016/S0165-5728(02)00205-9
PubMed reference number	12225886
Journal	Medline
Volume Number	130
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0165572802002059
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0165572802002059?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0165-5728%2802%2900205-9
Journal	Journal of Neuroimmunology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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