NDLI: Permanent, direct His-bundle pacing: a novel approach to cardiac pacing in patients with normal His-Purkinje activation.

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Permanent, direct His-bundle pacing: a novel approach to cardiac pacing in patients with normal His-Purkinje activation.

Content Provider	Semantic Scholar
Author	Deshmukh, Pramod M. Casavant, David A. Romanyshyn, Mary Anderson, Kristen
Copyright Year	2000
Abstract	BACKGROUND Direct His-bundle pacing (DHBP) produces synchronous ventricular depolarization and improved cardiac function relative to apical pacing. Although it has been performed transiently in the electrophysiology laboratory and persistently in open-chested canines, permanent DHBP in humans has not been achieved. METHODS AND RESULTS A total of 18 patients aged 69+/-10 years who had a history of chronic atrial fibrillation, dilated cardiomyopathy, and normal activation (ie, QRS< or =120 ms) were screened for permanent DHBP using an electrophysiology catheter. In 14 patients, the His bundle could be reliably stimulated. Of these 14, permanent DHBP using a fixed screw-in lead was successful in 12 patients. Radiofrequency atrioventricular node ablation was performed in patients exhibiting a fast ventricular response. All patients received single-chamber rate-responsive pacemakers. Acute pacing thresholds were 2.4+/-1.0 V at a pulse duration of 0.5 ms. Lead complications included exit block requiring reoperative adjustment and gross lead dislodgment. Echocardiographic improvement in heart function was shown by reductions in the left ventricular end-diastolic dimension from 59+/-8 to 52+/-6 mm (P
File Format	PDF HTM / HTML
DOI	10.1161/01.cir.101.8.869
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/101/8/869.full.pdf
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/101/8/869.full.pdf?download=true
PubMed reference number	10694526
Alternate Webpage(s)	https://doi.org/10.1161/01.cir.101.8.869
Journal	Medline
Volume Number	101
Issue Number	8
Journal	Circulation
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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