NDLI: Eugenol Inhibits K+ Currents in Trigeminal Ganglion Neurons

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Eugenol Inhibits K+ Currents in Trigeminal Ganglion Neurons

Content Provider	Semantic Scholar
Author	Li, Hai Ying Park, C-K Jung, Sung Jun Choi, S-Y Park, K. Kim, Jee Seon
Copyright Year	2007
Abstract	Eugenol, a natural capsaicin congener, is widely used in dentistry. Eugenol inhibits voltage-activated Na+ and Ca2+ channels in a transient receptor potential vanilloid 1 (TRPV1)-independent manner. We hypothesized that eugenol also inhibits voltage-gated K+ currents, and investigated this in rat trigeminal ganglion neurons and in a heterologous system using whole-cell patch clamping. Eugenol inhibited voltage-gated K+ currents, and the inhibitory effects of eugenol were observed in both capsaicin-sensitive and capsaicin-insensitive neurons. Pre-treatment with capsazepine, a well-known antagonist of TRPV1, failed to block the inhibitory effects of eugenol on K+ currents, suggesting no involvement of TRPV1. Eugenol inhibited human Kv1.5 currents stably expressed in Ltk − cells, where TRPV1 is not endogenously expressed. We conclude that eugenol inhibits voltage-gated K+ currents in a TRPV1-independent manner. The inhibition of voltage-gated K+ currents is likely to contribute to the irritable action of eugenol. Abbreviations: human Kv1.5 channel, hKv1.5; transient receptor potential vanilloid 1, TRPV1.
Starting Page	898
Ending Page	902
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1177/154405910708600918
PubMed reference number	17720863
Journal	Medline
Volume Number	86
Alternate Webpage(s)	http://jdr.sagepub.com/content/86/9/898.full.pdf
Alternate Webpage(s)	http://s-space.snu.ac.kr/bitstream/10371/47231/1/out.pdf
Alternate Webpage(s)	https://doi.org/10.1177/154405910708600918
Journal	Journal of dental research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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