Loading...
Please wait, while we are loading the content...
Similar Documents
Early airway infection, inflammation, and lung function in cystic fibrosis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nixon, Gillian M. Armstrong, David S. Carzino, Rosemary Carlin, John B. Olinsky, Anthony Robertson, Colin Francis Grimwood, Keith Wainwright, Claire |
| Copyright Year | 2002 |
| Abstract | AIMS To determine the relation between lower airway infection and inflammation, respiratory symptoms, and lung function in infants and young children with cystic fibrosis (CF). METHODS A prospective study of children with CF aged younger than 3 years, diagnosed by a newborn screening programme. All were clinically stable and had testing as outpatients. Subjects underwent bronchial lavage (BL) and lung function testing by the raised volume rapid thoracoabdominal compression technique under general anaesthesia. BL fluid was cultured and analysed for neutrophil count, interleukin 8, and neutrophil elastase. Lung function was assessed by forced expiratory volume in 0.5, 0.75, and 1 second. RESULTS Thirty six children with CF were tested on 54 occasions. Lower airway infection shown by BL was associated with a 10% reduction in FEV(0.5) compared with subjects without infection. No relation was identified between airway inflammation and lung function. Daily moist cough within the week before testing was reported on 20/54 occasions, but in only seven (35%) was infection detected. Independent of either infection status or airway inflammation, those with daily cough had lower lung function than those without respiratory symptoms at the time of BL (mean adjusted FEV(0.5) 195 ml and 236 ml respectively). CONCLUSIONS In young children with CF, both respiratory symptoms and airway infection have independent, additive effects on lung function, unrelated to airway inflammation. Further studies are needed to understand the mechanisms of airway obstruction in these young patients. |
| Starting Page | 175 |
| Ending Page | 175 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://adc.bmj.com/content/archdischild/87/4/306.full.pdf |
| PubMed reference number | 12244003v1 |
| Volume Number | 87 |
| Issue Number | 4 |
| Journal | Archives of disease in childhood |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Airway Obstruction Bronchoalveolar Lavage Fluid Chronic Obstructive Airway Disease Compression Coughing Cystic Fibrosis Expiration, function General Anesthesia HIV Infections Infant, Newborn Interleukins Irrigation Lymphangioma, Cystic Neonatal Screening Neutrophil count (procedure) Outpatients Pancreatic Elastase Patients Reactive airway disease Respiratory physiology Signs and Symptoms, Respiratory antineoplaston A10 |
| Content Type | Text |
| Resource Type | Article |
