NDLI: Embryonic treatment with xenobiotics disrupts steroid hormone profiles in hatchling red-eared slider turtles (Trachemys scripta elegans).

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Embryonic treatment with xenobiotics disrupts steroid hormone profiles in hatchling red-eared slider turtles (Trachemys scripta elegans).

Content Provider	Semantic Scholar
Author	Willingham, Emily Rhen, Turk Sakata, Jon T. Crews, David
Copyright Year	2000
Abstract	Many compounds in the environment capable of acting as endocrine disruptors have been assayed for their developmental effects on morphogenesis; however, few studies have addressed how such xenobiotics affect physiology. In the current study we examine the effects of three endocrine-disrupting compounds, chlordane, trans-nonachlor, and the polychlorinated biphenyl (PCB) mixture Aroclor 1242, on the steroid hormone concentrations of red-eared slider turtle (Trachemys scripta elegans) hatchlings treated in ovo. Basal steroid concentrations and steroid concentrations in response to follicle-stimulating hormone were examined in both male and female turtles treated with each of the three compounds. Treated male turtles exposed to Aroclor 1242 or chlordane exhibited significantly lower testosterone concentrations than controls, whereas chlordane-treated females had significantly lower progesterone, testosterone, and 5[alpha]-dihydrotestosterone concentrations relative to controls. The effects of these endocrine disruptors extend beyond embryonic development, altering sex-steroid physiology in exposed animals.
Starting Page	329
Ending Page	332
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1289/ehp.00108329
PubMed reference number	10753091
Journal	Medline
Volume Number	108
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/59/f4/envhper00305-0085.PMC1638010.pdf
Alternate Webpage(s)	https://doi.org/10.1289/ehp.00108329
Journal	Environmental health perspectives
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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