Loading...
Please wait, while we are loading the content...
Similar Documents
A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wood, Mildred Weigley Dongen, Hendrika M. A. Van Dongen, Antonius M. J. Van |
| Copyright Year | 1999 |
| Abstract | Alanine 714 of the NMDA receptor NR1 subunit resides in the glycine binding pocket. The Ala714Leu mutation substantially shifts glycine affinity, but here no effect on antagonism by DCK is detected. Ala714Leu is also found to limit the efficacy of a partial agonist without altering its apparent affinity. The differential sensitivity of Ala714Leu to glycine agonists suggests that alanine 714 may be an intermediary in transducing the ligand binding signal. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0169-328X(99)00247-8 |
| Alternate Webpage(s) | http://people.duke.edu/~av8/vandongen_lab/pdf%20files/alanine2.pdf |
| PubMed reference number | 10581413 |
| Alternate Webpage(s) | https://doi.org/10.1016/S0169-328X%2899%2900247-8 |
| Journal | Medline |
| Volume Number | 73 |
| Issue Number | 1-2 |
| Journal | Brain research. Molecular brain research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
