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Intrahepatic genetic inoculation of hepatitis C virus RNA confers cross-protective immunity.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Paliard, Xavier Medina-Selby, Angelica Coit, Doris Nguyen, Stéphanie Kansopon, Joe Arian, C. L. Ng, Philip Tucker, Julie Han, Jang Il Wong, Susan Lu, Hongbing Rosenberg, Stanley Chien, David M. Houghton, Michael |
| Copyright Year | 2001 |
| Abstract | Naturally occurring hepatitis C virus (HCV) infection has long been thought to induce a weak immunity which is insufficient to protect an individual from subsequent infections and has cast doubt on the ability to develop effective vaccines. A series of intrahepatic genetic inoculations (IHGI) with type 1a HCV RNA were performed in a chimpanzee to determine whether a form of genetic immunization might stimulate protective immunity. We demonstrate that the chimpanzee not only developed protective immunity to the homologous type 1a RNA after rechallenge by IHGI but was also protected from chronic HCV infection after sequential rechallenge with 100 50% chimpanzee infectious doses of a heterologous type 1a (H77) and 1b (HC-J4) whole-virus inoculum. These results offer encouragement to pursue the development of HCV vaccines. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jvi.asm.org/content/75/15/7142.full.pdf |
| PubMed reference number | 11435595v1 |
| Volume Number | 75 |
| Issue Number | 15 |
| Journal | Journal of virology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Databases, Genetic HCV viral load Hepatitis C virus Infection Murine sarcoma viruses Pan troglodytes RNA Rechallenge Vaccination alphanumeric label - 1A |
| Content Type | Text |
| Resource Type | Article |
