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Enantioselective α-arylation of aldehydes via the productive merger of iodonium salts and organocatalysis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Allen, Anna Elizabeth Millan, David W. C. Mac |
| Copyright Year | 2011 |
| Abstract | The enantioselective α-arylation of aldehydes has been accomplished using diaryliodonium salts and a combination of copper and organic catalysts. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-formyl benzylic stereocenters, a valuable synthon for the production of medicinal agents. As one example, this new asymmetric protocol has been applied to the rapid synthesis of (S)-ketoprofen, a commercially successful oral and topical analgesic. |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/ja2008906 |
| PubMed reference number | 21388207 |
| Journal | Medline |
| Volume Number | 133 |
| Issue Number | 12 |
| Alternate Webpage(s) | http://www.princeton.edu/chemistry/macmillan/publications/aldehyde-alpha-arylation.pdf |
| Alternate Webpage(s) | https://doi.org/10.1021/ja2008906 |
| Journal | Journal of the American Chemical Society |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
