NDLI: Martentoxin, a large-conductance Ca2+-activated K+ channel inhibitor, attenuated TNF-α-induced nitric oxide release by human umbilical vein endothelial cells

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Martentoxin, a large-conductance Ca2+-activated K+ channel inhibitor, attenuated TNF-α-induced nitric oxide release by human umbilical vein endothelial cells

Content Provider	Semantic Scholar
Author	Wang, Jun Qian, Wenyi Zhu, Qing Chen, Jian Chun Huan, Fei Gao, Rong Xiao, Hang
Copyright Year	2013
Abstract	Martentoxin, a 4,046 Da polypeptide toxin purified from the venom of the scorpion Buthus martensii Karsch, has been demonstrated to block large-conductance Ca(2+)-activated K(+) (BKCa) channels; however, its biological roles are still largely unknown. In the present study, we investigated the pharmacological effects of martentoxin on regulating the production of nitric oxide induced by TNF-α in human umbilical vein endothelial cells (HUVECs). We found that, 1, 10 and 100 µmol/L martentoxin decreased nitric oxide production by HUVECs exposed to 10 ng/mL TNF for 6, 12 and 24 hours. We further demonstrated that martentoxin inhibited the activity of iNOS and retarded the down-regulation of eNOS mRNA induced by TNF-α. Therefore, martentoxin could be a potential therapeutic agent for vascular diseases.
Starting Page	386
Ending Page	393
Page Count	8
File Format	PDF HTM / HTML
PubMed reference number	24086172
Alternate Webpage(s)	https://doi.org/10.7555/JBR.27.20120080
DOI	10.7555/jbr.27.20120080
Journal	Journal of biomedical research
Volume Number	27
Language	English
Access Restriction	Open
Subject Keyword	Calcium ion Down-Regulation Human Umbilical Vein Endothelial Cells NOS2A protein, human NOS3 gene Nitric Oxide Pharmacology Polypeptides Potassium Umbilicus (Anatomy) Vascular Diseases Venoms
Content Type	Text
Resource Type	Article

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