NDLI: Cytotoxic Activity of Flavonoids and Extracts from Retama sphaerocarpa Boissier

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Cytotoxic Activity of Flavonoids and Extracts from Retama sphaerocarpa Boissier

Content Provider	Semantic Scholar
Author	López-Lázaro, Miguel Martín-Cordero, Carmen Cortés, Felipe Piñero, Joaquín Ayuso, María Jesús Machuca
Copyright Year	2000
Abstract	Abstract Seven flavonoids isolated from chloroform , ethyl acetate and butanol extracts, obtained from the aerial parts of Retama sphaerocarpa, have been assessed for cytotoxic activity against three human cancer cell lines: TK-10 (renal adenocarcinom a), MCF-7 (breast adenocarcinom a) and UACC-62 (m elanom a), using the SRB assay. All of them , extracts and flavonoids, were actives in, at least, one of the three cell lines at the recom m ended N ational C ancer Institute doses. They produce a d ose-dependent inhibition of cell grow th at concentrations in the 10-6-10-4 ᴍ and 25 -250 μg/ml range for the flavonoids and extracts respectively, being the flavonol rhamnazin the most cytotoxic.
Starting Page	40
Ending Page	43
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1515/znc-2000-1-209
PubMed reference number	10739098
Journal	Medline
Volume Number	55
Alternate Webpage(s)	http://www.znaturforsch.com/ac/v55c/55c0040.pdf
Alternate Webpage(s)	https://www.degruyter.com/downloadpdf/j/znc.2000.55.issue-1-2/znc-2000-1-209/znc-2000-1-209.pdf
Alternate Webpage(s)	http://zfn.mpdl.mpg.de/data/Reihe_C/55/ZNC-2000-55c-0040.pdf
Journal	Zeitschrift fur Naturforschung. C, Journal of biosciences
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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