NDLI: Analysis of core housekeeping and virulence genes reveals cryptic lineages of Clostridium perfringens that are associated with distinct disease presentations.

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Analysis of core housekeeping and virulence genes reveals cryptic lineages of Clostridium perfringens that are associated with distinct disease presentations.

Content Provider	Semantic Scholar
Author	Friedman, Robert L. Maddox, Carol Wolfgang
Copyright Year	2006
Abstract	Clostridium perfringens is an important human and animal pathogen that causes a number of diseases that vary in their etiology and severity. Differences between strains regarding toxin gene composition and toxin production partly explain why some strains cause radically different diseases than others. However, they do not provide a complete explanation. The purpose of this study was to determine if there is a phylogenetic component that explains the variance in C. perfringens strain virulence by assessing patterns of genetic polymorphism in genes (colA gyrA, plc, pfoS, and rplL) that form part of the core genome in 248 type A strains. We found that purifying selection plays a central role in shaping the patterns of nucleotide substitution and polymorphism in both housekeeping and virulence genes. In contrast, recombination was found to be a significant factor only for the virulence genes plc and colA and the housekeeping gene gyrA. Finally, we found that the strains grouped into five distinct evolutionary lineages that show evidence of host adaptation and the early stages of speciation. The discovery of these previously unknown lineages and their association with distinct disease presentations carries important implications for human and veterinary clostridial disease epidemiology and provides important insights into the pathways through which virulence has evolved in C. perfringens.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.genetics.org/content/genetics/172/4/2081.full.pdf
Alternate Webpage(s)	http://www.genetics.org/content/early/2006/02/19/genetics.105.054601.full.pdf
PubMed reference number	16489222v1
Volume Number	172
Issue Number	4
Journal	Genetics
Language	English
Access Restriction	Open
Subject Keyword	Acclimatization Clostridium perfringens enterotoxin:PrThr:Pt:Body fld:Ord Clostridium perfringens enterotoxin:PrThr:Pt:Tiss:Ord Genetic Polymorphism Genus Cola Nucleotides Pathogenic organism Virulence
Content Type	Text
Resource Type	Article

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